Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses
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چکیده
منابع مشابه
Fv1, the mouse retrovirus resistance gene.
A number of genes which affect the susceptibility of mice to infection by retroviruses have been described. One of the most interesting of these genes is Fv1 (Friend virus susceptibility 1), which acts at a stage in the retroviral life-cycle following virus entry into the cell but prior to integration and formation of proviral structures. A detailed understanding of the mode of action of Fv1 mi...
متن کاملEvolution of the Retroviral Restriction Gene Fv1: Inhibition of Non-MLV Retroviruses
Fv1 is the prototypic restriction factor that protects against infection by the murine leukemia virus (MLV). It was first identified in cells that were derived from laboratory mice and was found to be homologous to the gag gene of an endogenous retrovirus (ERV). To understand the evolution of the host restriction gene from its retroviral origins, Fv1s from wild mice were isolated and characteri...
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15 صفحه اولIdentification of the myelin protein plasmolipin as the cell entry receptor for Mus caroli endogenous retrovirus.
The Asian wild mouse species Mus caroli harbors an endogenous retrovirus (McERV) that is closely related to but distinct from the endogenous retrovirus family defined by the Mus dunni endogenous virus and the Mus musculus endogenous retrovirus. McERV could infect some cell types from humans, dogs, and rats, but not all, and did not infect any mouse cell line tested. Because of its interesting h...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2020
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1008471